Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212310 | 0.84 | NCF1 (0.49) | HTR4GNAO1GNAI3GNAI1NCF1 | |
| SCHEMBL5215771 | 0.83 | HTR4 (0.47) | HTR4NCF1 | |
| SCHEMBL5216687 | 0.82 | HTR4 (0.48) | HTR4GNAO1GNAI3GNAI1NCF1 | |
| SCHEMBL5214688 | 0.82 | HTR4 (0.48) | HTR4NCF1 | |
| SCHEMBL5215967 | 0.82 | HTR4 (0.48) | HTR4NCF1 | |
| SCHEMBL5219363 | 0.81 | HTR4 (0.48) | HTR4GNAO1GNAI3GNAI1NCF1 | |
| SCHEMBL5306262 | 0.81 | HTR4 (0.46) | HTR4GNAO1GNAI3GNAI1 | |
| SCHEMBL5218999 | 0.80 | HTR4 (0.49) | HTR4NCF1 | |
| SCHEMBL5214555 | 0.78 | HTR4 (0.41) | HTR4NCF1 | |
| SCHEMBL960926 | 0.76 | HTR4 (0.43) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |