Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216394 | 1.00 | OPRM1 (0.47) | OPRM1OPRD1OPRK1BCHEKDM4E | |
| SCHEMBL5224863 | 0.93 | KDM4E (0.43) | OPRM1OPRD1OPRK1BCHEKDM4E | |
| SCHEMBL5224856 | 0.93 | KDM4E (0.43) | OPRM1OPRD1OPRK1BCHEKDM4E | |
| SCHEMBL5221710 | 0.90 | GAA (0.54) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL5221702 | 0.90 | GAA (0.54) | KDM4EMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL5219638 | 0.88 | ADRB3 (0.43) | OPRM1OPRD1OPRK1BCHEKDM4E | |
| SCHEMBL5219646 | 0.88 | ADRB3 (0.43) | OPRM1OPRD1OPRK1BCHEKDM4E | |
| SCHEMBL5223457 | 0.87 | CASR (0.46) | BCHECTSDADRB2ADRB1BACE1 | |
| SCHEMBL5223460 | 0.87 | CASR (0.46) | BCHECTSDADRB2ADRB1BACE1 | |
| SCHEMBL5219507 | 0.86 | SLC2A1 (0.46) | MEN1KMT2AALDH1A1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |