Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.46 |
| ▸ | CTSD | P07339 | 11/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223457 | 1.00 | CASR (0.46) | CASRCTSDADRB2ADRB1BCHE | |
| SCHEMBL5216401 | 0.87 | OPRM1 (0.47) | CTSDADRB2ADRB1BCHEBACE1 | |
| SCHEMBL5216394 | 0.87 | OPRM1 (0.47) | CTSDADRB2ADRB1BCHEBACE1 | |
| SCHEMBL5219027 | 0.86 | CASR (0.41) | CASRCTSDADRB2 | |
| SCHEMBL5219019 | 0.86 | CASR (0.41) | CASRCTSDADRB2 | |
| SCHEMBL5217991 | 0.83 | CASR (0.41) | CASRADRB2ADRB1BACE1 | |
| SCHEMBL5224863 | 0.82 | KDM4E (0.43) | CTSDADRB2ADRB1BCHEBACE1 | |
| SCHEMBL5224856 | 0.82 | KDM4E (0.43) | CTSDADRB2ADRB1BCHEBACE1 | |
| SCHEMBL5223492 | 0.82 | OPRM1 (0.40) | CASRADRB2ADRB1BCHEBACE1 | |
| SCHEMBL5223500 | 0.82 | OPRM1 (0.40) | CASRADRB2ADRB1BCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |