Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4681996 | 0.78 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4681997 | 0.78 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL5216594 | 0.77 | CYP11B2 (0.47) | ABCC9KCNJ11ABCC8KCNJ8POLB | |
| SCHEMBL5216587 | 0.77 | CYP11B2 (0.47) | ABCC9KCNJ11ABCC8KCNJ8POLB | |
| SCHEMBL4679942 | 0.77 | ABCC9 (0.46) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4679762 | 0.70 | ABCC9 (0.56) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4679754 | 0.70 | ABCC9 (0.56) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4683396 | 0.68 | ABCC9 (0.68) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4683403 | 0.68 | ABCC9 (0.68) | ABCC9KCNJ11ABCC8KCNJ8NAMPT | |
| SCHEMBL4685649 | 0.67 | ABCC9 (0.65) | ABCC9KCNJ11ABCC8KCNJ8NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198456-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2007-09-19 | — | — | EP | disclosed |