SCHEMBL521670

SCHEMBL521670

COC(=O)c1cc(F)cc(F)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.58
CA2 P00918 4/20 0.58
CA12 O43570 3/20 0.58
CA7 P43166 3/20 0.58
CA9 Q16790 3/20 0.58
CA14 Q9ULX7 3/20 0.58
KDM4E B2RXH2 3/20 0.56
LMNA P02545 2/20 0.56
XDH P47989 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
POLB P06746 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
GAA P10253 1/20 0.56
NFKB1 P19838 1/20 0.56
GFER P55789 1/20 0.56
NFKB2 Q00653 1/20 0.56
RELA Q04206 1/20 0.56
FUT7 Q11130 1/20 0.56
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1401499 0.95 CA1 (0.58) CA1CA2CA12CA7CA9
SCHEMBL1544732 0.87 HCAR1 (0.53) CA1CA2CA12CA7CA9
SCHEMBL30822018 0.87 HCAR1 (0.53) CA1CA2CA12CA7CA9
SCHEMBL16952776 0.87 KDM4E (0.51) CA1CA2CA12CA7CA9
SCHEMBL851412 0.87 CA12 (0.73) CA1CA2CA12CA7CA9
SCHEMBL1544913 0.87 ATM (0.52) CA1CA2CA12CA7CA9
SCHEMBL24526561 0.86 CA12 (0.48) CA1CA2CA12CA7CA9
SCHEMBL2825430 0.86 NOTUM (0.62) CA1CA2CA12CA7CA9
SCHEMBL17462467 0.86 CA1 (0.52) CA1CA2CA12CA7CA9
SCHEMBL16679871 0.86 CA12 (0.48) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109651376-B Synthetic method of azepino [5,4,3-cd ] indol-6-one compound 江苏创诺制药有限公司 2022-06-03 CN claimed
CN-109651376-A A kind of synthetic method of azatropylidene simultaneously [5,4,3-cd] indoles -6- ketone compound 江苏创诺制药有限公司 2019-04-19 CN claimed
US-20250122171-A1 Substituted Amine Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. 2025-04-17 US disclosed
WO-2025064534-A1 SUBSTITUTED AMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2025-03-27 WO disclosed
CN-119569569-A 1-Vinyl cyclobutene derivative and synthetic method and application thereof 南宁师范大学 2025-03-07 CN disclosed
WO-2025011546-A1 HUMAN CASEINOLYTIC PROTEASE P AGONISTS AND USES THEREOF ACELON THERAPEUTICS (CN) 2025-01-16 WO disclosed
CN-117321046-A Indazole-based compounds and related methods of use 阿维纳斯企业公司 2023-12-29 CN disclosed
CN-114369121-B Metal complexes, polymers, mixtures, compositions and organic electronic devices 广州华睿光电材料有限公司 2023-12-01 CN disclosed
CN-117098750-A Molecules having pesticidal utility, and intermediates and methods related thereto 科迪华农业科技有限责任公司 2023-11-21 CN disclosed
US-20230359119-A1 RESIST COMPOSITION AND PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-11-09 US disclosed
CN-116940567-A Agonists of the interferon gene stimulator STING 斯克里普斯研究学院 2023-10-24 CN disclosed
CN-1654452-A Method of producing carboxylate DALIAN LUYUAN PHARMACY CO LTD (CN) 2005-08-17 CN disclosed
US-20050170529-A1 Metal chelates and methods of using them for time-resolved fluorescence IDEXX LABORATORIES, INC., A DELAWARE CORPORATION 2005-08-04 US disclosed
EP-1556323-A2 METAL CHELATES AND METHODS OF USING THEM FOR TIME-RESOLVED FLUORESCENCE IDEXX LABORATORIES, INC. (US) 2005-07-27 EP disclosed
CN-1646426-A Metallized mesoporous silicate and method of oxidation with the same SUMITOMO CHEMICAL CO (JP) 2005-07-27 CN disclosed
US-20050090688-A1 Metallized mesoporous silicate and method of oxidation with the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-04-28 US disclosed
EP-1473275-A1 METALLIZED MESOPOROUS SILICATE AND METHOD OF OXIDATION WITH THE SAME Sumitomo Chemical Company, Limited (JP) 2004-11-03 EP disclosed
WO-2004040534-A2 METAL CHELATES AND METHODS OF USING THEM FOR TIME-RESOLVED FLUORESCENCE IDEXX LABORATORIES, INC. (US) 2004-05-13 WO disclosed
US-20040082768-A1 Metal chelates and methods of using them for time-resolved fluorescence IDEXX LABORATORIES INC. 2004-04-29 US disclosed
EP-1329160-A2 4-ACYLAMINOPYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-07-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122171-A1 Substituted Amine Compounds, Compositions and Methods of Use MRGPRX2, MRGPRX1, MRGPRX4 CA1 3238/4885CA2 2467/4885CA12 2359/4885
US-20050170529-A1 Metal chelates and methods of using them for time-resolved fluorescence MARK3, PRKD3, ULK3 CA1 4357/4885CA2 3501/4885CA12 4475/4885
US-20040082768-A1 Metal chelates and methods of using them for time-resolved fluorescence MARK3, ULK3, PRKD3 CA1 4434/4885CA2 3511/4885CA12 4515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.