Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.58 |
| ▸ | BRD2 | P25440 | 10/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12095520 | 0.82 | BRD4 (0.57) | BRD4BRD2CREBBPHDAC1BRD3 | |
| SCHEMBL12881340 | 0.78 | BRD4 (0.59) | BRD4BRD2CREBBPBRD3FFAR1 | |
| SCHEMBL12487 | 0.76 | NPC1 (0.69) | BRD4BRD2CREBBPBRD3MAP4K4 | |
| SCHEMBL1904650 | 0.73 | DHODH (0.66) | BRD4BRD2CREBBPHDAC1CYP3A4 | |
| SCHEMBL16404612 | 0.73 | BRD4 (0.62) | BRD4BRD2CREBBPBRD3MAP4K4 | |
| SCHEMBL16246450 | 0.73 | BRD4 (0.62) | BRD4BRD2CREBBPBRD3MAP4K4 | |
| SCHEMBL980536 | 0.73 | MAP4K4 (0.76) | BRD4BRD2CREBBPBRD3MAP4K4 | |
| SCHEMBL9657290 | 0.73 | BRD4 (0.62) | BRD4BRD2CREBBPHDAC1BRD3 | |
| SCHEMBL16675743 | 0.73 | BRD4 (0.58) | BRD4BRD2CREBBPHDAC1BRD3 | |
| SCHEMBL20946455 | 0.73 | BRD4 (0.57) | BRD4BRD2CREBBPBRD3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581516-A4 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1581516-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047744-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |