Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124039 | 0.84 | MAPK14 (0.63) | MAPK14MAP2K1LCKCSF1RKDR | |
| SCHEMBL5220199 | 0.78 | MAPK14 (0.50) | MAPK14MAP2K1NPC1RAB9AMAPK11 | |
| SCHEMBL5220245 | 0.77 | MAPK14 (0.61) | MAPK14MAP2K1LCKCSF1RKDR | |
| SCHEMBL5114250 | 0.76 | MAPK14 (0.64) | MAPK14MAP2K1LCKNPC1RAB9A | |
| SCHEMBL5123466 | 0.70 | MAPK14 (0.72) | MAPK14MAP2K1LCKCSF1RKDR | |
| SCHEMBL5216405 | 0.69 | MAPK14 (0.57) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5117599 | 0.69 | MAPK14 (0.64) | MAPK14MAP2K1LCKCSF1RKDR | |
| SCHEMBL5124579 | 0.69 | MAPK14 (0.63) | MAPK14MAP2K1LCKCSF1RKDR | |
| SCHEMBL9898434 | 0.68 | GCK (0.55) | — | |
| SCHEMBL2724357 | 0.67 | GCK (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |