Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116940 | 0.83 | MAPK14 (0.79) | MAPK14MAPK11MAP2K1LCKCSF1R | |
| SCHEMBL5217308 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11MAP2K1LCKCSF1R | |
| SCHEMBL5216405 | 0.77 | MAPK14 (0.57) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL5464918 | 0.76 | MAPK14 (1.00) | MAPK14MAPK11 | |
| SCHEMBL5216080 | 0.74 | MAPK14 (0.88) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL5118009 | 0.73 | MAPK14 (1.00) | MAPK14MAPK11MAP2K1LCKCSF1R | |
| SCHEMBL5123466 | 0.71 | MAPK14 (0.72) | MAPK14MAPK11MAP2K1LCKCSF1R | |
| SCHEMBL5220199 | 0.70 | MAPK14 (0.50) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL14470498 | 0.69 | RAB9A (0.47) | — | |
| SCHEMBL14470490 | 0.69 | POLB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |