Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223581 | 0.97 | KMT2A (0.43) | MEN1KMT2ATPMTVCAM1HPGD | |
| SCHEMBL5224653 | 0.88 | MEN1 (0.44) | MEN1KMT2AVCAM1HPGDMAPT | |
| SCHEMBL5223575 | 0.86 | TPMT (0.43) | MEN1KMT2ATPMTVCAM1HPGD | |
| SCHEMBL5220082 | 0.84 | MEN1 (0.43) | MEN1KMT2AVCAM1HPGDMAPT | |
| SCHEMBL5220487 | 0.81 | KDM4E (0.47) | HPGDMAPTGAAKDM4EALDH1A1 | |
| SCHEMBL5221138 | 0.78 | KDM4E (0.49) | HPGDMAPTGAAKDM4EALDH1A1 | |
| SCHEMBL5222633 | 0.78 | CTSD (0.48) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL5219336 | 0.77 | TPMT (0.48) | MEN1KMT2ATPMTVCAM1HPGD | |
| SCHEMBL5220771 | 0.77 | ALDH1A1 (0.42) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5224649 | 0.76 | MEN1 (0.42) | MEN1KMT2AVCAM1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |