Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217933 | 0.82 | HPGD (0.56) | HPGDALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL6053636 | 0.78 | HSD17B10 (0.41) | HPGDVDRALDH1A1HSD17B10KDM4E | |
| SCHEMBL5222285 | 0.78 | CA12 (0.48) | HPGDALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL5072409 | 0.75 | VDR (0.39) | HPGDVDRALDH1A1HSD17B10KDM4E | |
| SCHEMBL8536518 | 0.73 | ALDH1A1 (0.51) | HPGDALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11594175 | 0.73 | ALDH1A1 (0.52) | VDRALDH1A1KDM4EHTTGLA | |
| SCHEMBL11593802 | 0.73 | ALDH1A1 (0.52) | VDRALDH1A1KDM4EHTTGLA | |
| SCHEMBL5219920 | 0.73 | CYP1A2 (0.43) | HPGDVDRALDH1A1HSD17B10KDM4E | |
| SCHEMBL11592549 | 0.72 | HSD17B2 (0.56) | HPGDALDH1A1KDM4EMAPTCYP2C19 | |
| SCHEMBL11591611 | 0.72 | HSD17B2 (0.56) | ALDH1A1KDM4EMAPTCYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368318-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-12-05 | — | — | EP | disclosed |
| US-6864267-B2 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1368318-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030212110-A1 | Glandular disorders; bone disorders | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| WO-2002007673-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212110-A1 | Glandular disorders; bone disorders | CYP24A1, PTH1R, SOST | HPGD 87/4885VDR 10/4885ALDH1A1 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.