Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MDH1 | P40925 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219254 | 0.76 | KDM4E (0.42) | ALDH1A1TDP1TSHRKDM4EHSD17B10 | |
| SCHEMBL5306835 | 0.76 | TP53 (0.32) | — | |
| SCHEMBL5220005 | 0.76 | TP53 (0.30) | — | |
| SCHEMBL5224165 | 0.73 | ALDH1A1 (0.47) | ALDH1A1PKMTDP1TSHRKDM4E | |
| SCHEMBL5222005 | 0.72 | MAPT (0.44) | ALDH1A1TDP1KDM4EHPGDKMT2A | |
| SCHEMBL5217023 | 0.72 | ALDH1A1 (0.46) | ALDH1A1PKMTDP1TSHRKDM4E | |
| SCHEMBL5225585 | 0.72 | CYP2C9 (0.38) | ALDH1A1TDP1TSHRHSD17B10HPGD | |
| SCHEMBL5221511 | 0.69 | ALDH1A1 (0.39) | ALDH1A1PKMTDP1TSHRKDM4E | |
| SCHEMBL5221827 | 0.69 | KDM4E (0.41) | ALDH1A1PKMTDP1TSHRKDM4E | |
| SCHEMBL475604 | 0.68 | ALDH1A1 (0.53) | ALDH1A1PKMTDP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |