Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 5/20 | 0.41 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217768 | 1.00 | KLK5 (0.52) | KLK5CTSLPSEN1PSEN2APH1B | |
| SCHEMBL5225871 | 0.80 | KLK5 (0.57) | KLK5CTSLPSEN1PSEN2APH1B | |
| SCHEMBL7877924 | 0.79 | KLK5 (0.52) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5378900 | 0.79 | F2 (0.39) | CTSL | |
| Hydrochloric Acid SCHEMBL5224811 | 0.78 | LMNA (0.40) | — | |
| SCHEMBL7309908 | 0.75 | KLK5 (0.65) | KLK5CTSLPSEN1PSEN2APH1B | |
| SCHEMBL5383365 | 0.75 | F2 (0.40) | CTSL | |
| SCHEMBL5218395 | 0.75 | SLC2A1 (0.37) | CTSL | |
| SCHEMBL5396616 | 0.74 | KLK5 (0.61) | KLK5CTSLPSEN1PSEN2APH1B | |
| SCHEMBL5396623 | 0.74 | KLK5 (0.61) | KLK5CTSLPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |