Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31415554 | 0.87 | ACHE (0.59) | ACHEPIK3CGPIK3CDMTORMAPT | |
| SCHEMBL981283 | 0.84 | ACHE (1.00) | ACHEMAPTTP53LMNATHRB | |
| SCHEMBL13415305 | 0.78 | ACHE (0.80) | ACHEMAPTTP53LMNATHRB | |
| SCHEMBL21939240 | 0.78 | ACHE (0.59) | ACHEPIK3CGPIK3CDMTORMAPT | |
| SCHEMBL27436286 | 0.78 | ACHE (0.64) | ACHEPIK3CGPIK3CDMTORMAPT | |
| SCHEMBL30955218 | 0.78 | ACHE (0.64) | ACHEPIK3CGPIK3CDMTORMAPT | |
| SCHEMBL5122825 | 0.77 | NR1H4 (0.60) | ACHEMAPTTP53MAPK14 | |
| SCHEMBL3783964 | 0.76 | ALDH1A1 (0.54) | ACHEMAPTTP53LMNANPC1 | |
| SCHEMBL2092192 | 0.75 | NPC1 (0.63) | ACHEMAPTTP53MAPK14LMNA | |
| SCHEMBL61991 | 0.74 | ACHE (0.64) | ACHEMAPTTP53BCHEHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |