Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 4/20 | 0.44 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218168 | 1.00 | CTSD (0.44) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL5224081 | 0.87 | BACE1 (0.48) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL5224073 | 0.87 | BACE1 (0.48) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL5220607 | 0.81 | VIPR2 (0.43) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL5220613 | 0.81 | VIPR2 (0.43) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL5225206 | 0.81 | VIPR2 (0.43) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL5225215 | 0.81 | VIPR2 (0.43) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL5223477 | 0.79 | BACE1 (0.44) | CTSDBACE1BACE2 | |
| SCHEMBL4693111 | 0.79 | BACE1 (0.41) | CTSDBACE1BACE2 | |
| SCHEMBL5223476 | 0.79 | BACE1 (0.44) | CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |