Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | CTSD | P07339 | 2/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224081 | 1.00 | BACE1 (0.48) | BACE1CTSDBACE2ACHEKDM1A | |
| SCHEMBL5218168 | 0.87 | CTSD (0.44) | BACE1CTSDBACE2ACHEMAOA | |
| SCHEMBL5218164 | 0.87 | CTSD (0.44) | BACE1CTSDBACE2ACHEMAOA | |
| SCHEMBL5223365 | 0.81 | CTSD (0.49) | BACE1CTSDBACE2ACHEKDM1A | |
| SCHEMBL7613311 | 0.76 | BACE1 (0.60) | BACE1CTSDBACE2KDM1AMAOA | |
| SCHEMBL7613304 | 0.76 | BACE1 (0.60) | BACE1CTSDBACE2KDM1AMAOA | |
| SCHEMBL4045255 | 0.75 | KDM1A (0.49) | BACE1CTSDBACE2KDM1AMAOA | |
| SCHEMBL4041567 | 0.75 | KDM1A (0.49) | BACE1CTSDBACE2KDM1AMAOA | |
| SCHEMBL5223460 | 0.74 | CASR (0.46) | BACE1CTSDMTNR1AMTNR1B | |
| SCHEMBL5223457 | 0.74 | CASR (0.46) | BACE1CTSDMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |