Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226263 | 0.89 | NOX1 (0.42) | PTGER1HTTATRATRIPNOX1 | |
| SCHEMBL2654597 | 0.86 | GCK (0.44) | HTTNOX1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL5218574 | 0.84 | PTGER1 (0.44) | PTGER1HTTATRATRIPNOX1 | |
| SCHEMBL2666934 | 0.81 | NOX1 (0.44) | HTTNOX1ALDH1A1MAPK1PKM | |
| SCHEMBL5221627 | 0.79 | NOX1 (0.45) | HTTNOX1ALDH1A1MAPK1PKM | |
| SCHEMBL14381218 | 0.78 | NOX1 (0.34) | PTGER1ATRATRIPNOX1NOS1 | |
| SCHEMBL3371103 | 0.77 | HTT (0.60) | PTGER1HTTNOX1ALDH1A1MAPK1 | |
| SCHEMBL16471641 | 0.74 | KCNA3 (0.44) | KCNA3ALDH1A1MAPK1MRGPRX4 | |
| SCHEMBL15417869 | 0.73 | REN (0.47) | KCNA3PKM | |
| SCHEMBL18585491 | 0.73 | CA12 (0.51) | HTTKCNA3ALDH1A1MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578745-B1 | BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | EP | disclosed |