Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 9/20 | 0.40 |
| ▸ | RAB9A | P51151 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | GCK | P35557 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654597 | 0.92 | GCK (0.44) | NOX1ALDH1A1MAPK1SMN1; SMN2HTT | |
| SCHEMBL2666934 | 0.91 | NOX1 (0.44) | NOX1ALDH1A1MAPK1SMN1; SMN2HTT | |
| SCHEMBL5221067 | 0.89 | GCK (0.51) | NOX1ALDH1A1MAPK1SMN1; SMN2HTT | |
| SCHEMBL5226263 | 0.87 | NOX1 (0.42) | NOX1ALDH1A1MAPK1HTTRAB9A | |
| SCHEMBL5217769 | 0.81 | GCK (0.55) | NOX1GCKTSHRMEN1MAPT | |
| SCHEMBL2654604 | 0.81 | GCK (0.51) | NOX1ALDH1A1MAPK1SMN1; SMN2HTT | |
| SCHEMBL5218374 | 0.79 | PTGER1 (0.45) | NOX1ALDH1A1MAPK1SMN1; SMN2HTT | |
| SCHEMBL2650573 | 0.77 | GCK (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL5222914 | 0.73 | NOX1 (0.42) | NOX1SMN1; SMN2HTTGCKKCNH2 | |
| SCHEMBL2655556 | 0.72 | GCK (0.52) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578745-B1 | BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | EP | disclosed |