Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218374 | 0.89 | PTGER1 (0.45) | NOX1KCNA3PTGER1ACACBEPHA2 | |
| SCHEMBL5221627 | 0.87 | NOX1 (0.45) | NOX1MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL5222914 | 0.84 | NOX1 (0.42) | NOX1METAP2PTGER1ACACBMEN1 | |
| SCHEMBL2654597 | 0.80 | GCK (0.44) | NOX1ALDH1A1MAPK1HTTTP53 | |
| SCHEMBL2666934 | 0.79 | NOX1 (0.44) | NOX1MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL31359519 | 0.78 | HPGD (0.55) | KCNA3MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL14381218 | 0.76 | NOX1 (0.34) | NOX1PTGER1ACACBEPHA2KDR | |
| SCHEMBL18585480 | 0.76 | KDM4E (0.48) | KCNA3MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL3523312 | 0.75 | MAOB (0.43) | NOX1KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL5221067 | 0.74 | GCK (0.51) | NOX1ALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578745-B1 | BENZOFURAN DERIVATivES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | EP | disclosed |