⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1235991 | 0.82 | — | — | |
| SCHEMBL6720419 | 0.80 | — | — | |
| SCHEMBL4047411 | 0.79 | CYP2D6 (0.45) | — | |
| SCHEMBL31613206 | 0.76 | CYP2D6 (0.43) | — | |
| SCHEMBL322077 | 0.75 | — | — | |
| SCHEMBL6722022 | 0.75 | — | — | |
| SCHEMBL19137715 | 0.75 | TSHR (0.48) | — | |
| Ethylene SCHEMBL8519352 | 0.73 | CYP2D6 (0.41) | — | |
| SCHEMBL8958360 | 0.73 | KDM4E (0.43) | — | |
| SCHEMBL6721942 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018368-B1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2012-12-05 | — | — | EP | claimed |
| CN-101410378-B | Malonamide derivatives as gamma secretase inhibitors | HOFFMANN LA ROCHE | 2012-12-05 | — | — | CN | claimed |
| EP-2018368-A1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-01-28 | — | — | EP | claimed |
| US-7425551-B2 | Malonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-16 | — | — | US | claimed |
| WO-2007110335-A1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | claimed |
| US-20070225273-A1 | Malonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | US | claimed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | claimed |
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | HOFFMAN-LA ROCHE INC. | 2005-04-07 | — | — | US | claimed |
| US-20250296912-A1 | AFFINITY ILLUDOFULVENE CONJUGATES | Illudent, Inc. (US) | 2025-09-25 | — | — | US | disclosed |
| US-12269793-B2 | Affinity illudofulvene conjugates | AF CHEMICALS, LLC (US) | 2025-04-08 | — | — | US | disclosed |
| US-11932647-B2 | Cyclic iminopyrimidine derivatives as kinase inhibitors | ABM THERAPEUTICS CORPORATION (US) | 2024-03-19 | — | — | US | disclosed |
| EP-3684772-B1 | CYCLIC IMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ABM THERAPEUTICS CORP (US) | 2023-12-06 | — | — | EP | disclosed |
| US-20230357199-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. | 2023-11-09 | — | — | US | disclosed |
| US-11708351-B2 | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| EP-0604491-A1 | SUBSTITUTED 3-PHENYLURACILS AS HERBICIDES | BASF Aktiengesellschaft (DE) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006090-A1 | SUBSTITUTED 3-PHENYLURACILS AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1993-04-01 | — | — | WO | disclosed |
| US-4927508-A | Alkyl 2-fluoro-1-methoxyethylcarbamates | THE DOW CHEMICAL COMPANY (US) | 1990-05-22 | — | — | US | disclosed |
| US-4927508-A | Alkyl 2-fluoro-1-methoxyethylcarbamates | THE DOW CHEMICAL COMPANY (US) | 1990-05-22 | — | — | US | disclosed |
| US-4845267-A | Alkyl 2-fluoro-1-methoxyethylcarbamates | THE DOW CHEMICAL COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| US-4845267-A | Alkyl 2-fluoro-1-methoxyethylcarbamates | THE DOW CHEMICAL COMPANY (US) | 1989-07-04 | — | — | US | disclosed |