Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499087 | 0.83 | LTA4H (0.43) | BACE1LTA4HMAPK14ROCK1 | |
| SCHEMBL5036404 | 0.82 | NOS2 (0.46) | BACE1DHFRROCK1KCNH2NR3C2 | |
| SCHEMBL5216556 | 0.82 | BACE1 (0.42) | MAOAMAOBBACE1ROCK1ROCK2 | |
| SCHEMBL8132827 | 0.79 | BACE1 (0.66) | MAOAMAOBBACE1DHFRKDM4E | |
| SCHEMBL5033897 | 0.79 | HRH1 (0.52) | MAOAMAOBABCB1HTR1ADRD2 | |
| SCHEMBL21463485 | 0.77 | NPC1 (0.45) | DHFRKDM4ELTA4HROCK1 | |
| SCHEMBL6031149 | 0.75 | NOS2 (0.53) | KDM4E | |
| SCHEMBL27405845 | 0.75 | NOS2 (0.43) | BACE1KDM4E | |
| SCHEMBL5038010 | 0.74 | SMN1; SMN2 (0.50) | LTA4HMAPK14ROCK1ROCK2KCNH2 | |
| SCHEMBL5249618 | 0.74 | MPO (0.46) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |