Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219027 | 1.00 | CASR (0.41) | CASRSLC2A1RIPK1OPRM1OPRD1 | |
| SCHEMBL5219515 | 0.87 | SLC2A1 (0.46) | SLC2A1ADRB3MEN1ALDH1A1HPGD | |
| SCHEMBL5219507 | 0.87 | SLC2A1 (0.46) | SLC2A1ADRB3MEN1ALDH1A1HPGD | |
| SCHEMBL5223457 | 0.86 | CASR (0.46) | CASRADRB2CTSD | |
| SCHEMBL5223460 | 0.86 | CASR (0.46) | CASRADRB2CTSD | |
| SCHEMBL5930323 | 0.85 | SLC6A2 (0.43) | SLC2A1RIPK1SLC6A2SLC6A4LMNA | |
| SCHEMBL5930327 | 0.85 | SLC6A2 (0.43) | SLC2A1RIPK1SLC6A2SLC6A4LMNA | |
| SCHEMBL5223492 | 0.83 | OPRM1 (0.40) | CASRRIPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5223500 | 0.83 | OPRM1 (0.40) | CASRRIPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL5218395 | 0.81 | SLC2A1 (0.37) | SLC2A1RIPK1PTGESLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |