Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223492 | 1.00 | OPRM1 (0.40) | OPRM1OPRD1OPRK1RIPK1BACE1 | |
| SCHEMBL5216463 | 0.88 | BACE1 (0.43) | OPRM1OPRD1OPRK1BACE1CASR | |
| SCHEMBL5216472 | 0.88 | BACE1 (0.43) | OPRM1OPRD1OPRK1BACE1CASR | |
| SCHEMBL5217991 | 0.85 | CASR (0.41) | OPRM1OPRD1OPRK1BACE1ADRB2 | |
| SCHEMBL5219393 | 0.85 | CASR (0.41) | OPRM1OPRD1OPRK1BACE1ADRB2 | |
| SCHEMBL5219382 | 0.85 | CASR (0.41) | OPRM1OPRD1OPRK1BACE1ADRB2 | |
| SCHEMBL5223463 | 0.85 | OPRD1 (0.41) | OPRM1OPRD1OPRK1RIPK1BACE1 | |
| SCHEMBL5223473 | 0.85 | OPRD1 (0.41) | OPRM1OPRD1OPRK1RIPK1BACE1 | |
| SCHEMBL5223621 | 0.83 | OPRM1 (0.36) | OPRM1OPRD1OPRK1BACE1ABCB1 | |
| SCHEMBL5219019 | 0.83 | CASR (0.41) | OPRM1OPRD1OPRK1RIPK1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |