Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219875 | 0.85 | NPC1 (0.47) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL7240806 | 0.84 | KDM4E (0.65) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL5219674 | 0.82 | CYP2C9 (0.45) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL5223591 | 0.82 | CYP2C9 (0.45) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL5226061 | 0.81 | MEN1 (0.48) | NPC1KDM4ESMN1; SMN2CYP2C9CYP3A4 | |
| SCHEMBL5223383 | 0.81 | CTSD (0.47) | HSD17B10CYP2C9CYP3A4MEN1KMT2A | |
| SCHEMBL475775 | 0.77 | MEN1 (0.56) | NPC1RAB9ASMN1; SMN2CYP2C9CYP3A4 | |
| SCHEMBL5219444 | 0.77 | MEN1 (0.56) | NPC1RAB9ASMN1; SMN2CYP2C9CYP3A4 | |
| SCHEMBL5223336 | 0.76 | CYP2C9 (0.44) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9077842 | 0.75 | KDM4E (0.58) | HSD17B10NPC1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |