Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219875 | 0.92 | NPC1 (0.47) | CYP2C9CYP3A4MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL5222262 | 0.90 | ALDH1A1 (0.50) | CYP2C9CYP3A4MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL5218289 | 0.86 | CTSD (0.50) | CYP2C9CYP3A4MAPTSMN1; SMN2MEN1 | |
| SCHEMBL5219336 | 0.86 | TPMT (0.48) | CYP2C9CYP3A4MAPTSMN1; SMN2MEN1 | |
| SCHEMBL5219674 | 0.85 | CYP2C9 (0.45) | CYP2C9CYP3A4MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL5219617 | 0.82 | HSD17B10 (0.50) | CYP2C9CYP3A4MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL15596207 | 0.81 | KDM4E (0.50) | CYP2C9CYP3A4MAPTSMN1; SMN2ATM | |
| SCHEMBL5219444 | 0.80 | MEN1 (0.56) | CYP2C9CYP3A4MAPTSMN1; SMN2MEN1 | |
| SCHEMBL475775 | 0.80 | MEN1 (0.56) | CYP2C9CYP3A4MAPTSMN1; SMN2MEN1 | |
| SCHEMBL7240806 | 0.79 | KDM4E (0.65) | CYP2C9CYP3A4MAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |