Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220855 | 0.90 | CTSD (0.50) | CTSDBACE1BACE2CYP2C9CYP3A4 | |
| SCHEMBL5218289 | 0.87 | CTSD (0.50) | CTSDBACE1BACE2CYP2C9CYP3A4 | |
| SCHEMBL5219617 | 0.81 | HSD17B10 (0.50) | CYP2C9CYP3A4CASP6TDP1L3MBTL1 | |
| SCHEMBL5219544 | 0.80 | CTSD (0.52) | CTSDBACE1BACE2CYP2C9CYP3A4 | |
| SCHEMBL5222480 | 0.78 | CTSD (0.44) | CTSDBACE1BACE2TP53MAPT | |
| SCHEMBL5218030 | 0.77 | BACE1 (0.47) | CTSDBACE1BACE2HPGDHSD17B10 | |
| SCHEMBL5219674 | 0.77 | CYP2C9 (0.45) | CYP2C9CYP3A4L3MBTL1HPGDHSD17B10 | |
| SCHEMBL5223591 | 0.77 | CYP2C9 (0.45) | CYP2C9CYP3A4CASP6TDP1L3MBTL1 | |
| SCHEMBL5226061 | 0.76 | MEN1 (0.48) | CYP2C9CYP3A4TDP1L3MBTL1HPGD | |
| SCHEMBL5218025 | 0.76 | BACE1 (0.41) | CTSDBACE1BACE2ALDH1A1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |