Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217402 | 0.88 | LMNA (0.43) | ALDH1A1MAPTLMNATSHRHTT | |
| SCHEMBL5223526 | 0.83 | HSD11B1 (0.43) | MAPTLMNATSHRHTTHPGD | |
| SCHEMBL1154474 | 0.79 | CYP11B1 (0.43) | ALDH1A1MAPTLMNATSHRHTT | |
| SCHEMBL5216704 | 0.79 | MAPT (0.42) | ALDH1A1KDM4EMAPTLMNATSHR | |
| SCHEMBL5225071 | 0.78 | CASR (0.51) | MAPTLMNATSHRHTT | |
| SCHEMBL5217387 | 0.77 | CASR (0.41) | ALDH1A1MAPTLMNATSHRHTT | |
| SCHEMBL23704670 | 0.77 | LMNA (0.40) | ALDH1A1MAPTLMNATSHRHTT | |
| SCHEMBL17427512 | 0.76 | HTR1B (0.40) | ALDH1A1KDM4EMAPTLMNATSHR | |
| SCHEMBL1154287 | 0.76 | MCL1 (0.55) | ALDH1A1KDM4EMAPTLMNAHTT | |
| SCHEMBL5217886 | 0.75 | HRH1 (0.41) | ALDH1A1KDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |