Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NRP1 | O14786 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217402 | 0.89 | LMNA (0.43) | LMNAMAPTTSHRHTTTAAR1 | |
| SCHEMBL1154503 | 0.86 | HSD11B1 (0.50) | HSD11B1LMNAMAPTTSHRHTT | |
| SCHEMBL5219882 | 0.83 | ALDH1A1 (0.46) | LMNAMAPTTSHRHTTHPGD | |
| SCHEMBL1154474 | 0.80 | CYP11B1 (0.43) | LMNAMAPTTSHRHTTMRGPRX4 | |
| SCHEMBL5216704 | 0.80 | MAPT (0.42) | CASRLMNAMAPTTSHRHTT | |
| SCHEMBL1155054 | 0.80 | NPC1 (0.52) | CASRLMNAMAPTTSHRHTT | |
| SCHEMBL5221531 | 0.79 | CASR (0.41) | KCNH2CASRLMNAMAPTTSHR | |
| SCHEMBL5217387 | 0.79 | CASR (0.41) | KCNH2CASRLMNAMAPTTSHR | |
| SCHEMBL23704670 | 0.78 | LMNA (0.40) | LMNAMAPTTSHRHTTTAAR1 | |
| SCHEMBL2164306 | 0.78 | HSD11B1 (0.41) | HSD11B1CASRP2RX7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |