Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 9/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222594 | 0.89 | POLB (0.39) | CTSDBACE1BACE2PTGER3HCAR3 | |
| SCHEMBL5218370 | 0.88 | PTGER3 (0.37) | CTSDBACE1BACE2PTGER3PDE4B | |
| SCHEMBL5220117 | 0.79 | BACE1 (0.37) | CTSDBACE1BACE2KDM4EALDH1A1 | |
| SCHEMBL5218380 | 0.78 | PIK3C3 (0.39) | CTSDBACE1BACE2PTGER3PDE4B | |
| SCHEMBL5219279 | 0.77 | CTSD (0.51) | CTSDBACE1BACE2PTGER3KDM4E | |
| SCHEMBL5221391 | 0.77 | BACE1 (0.56) | CTSDBACE1BACE2 | |
| SCHEMBL5219130 | 0.76 | CTSD (0.37) | CTSDBACE1BACE2 | |
| SCHEMBL5218348 | 0.76 | BACE1 (0.37) | CTSDBACE1BACE2KDM4EALDH1A1 | |
| SCHEMBL5218440 | 0.74 | BACE1 (0.58) | CTSDBACE1BACE2 | |
| SCHEMBL5218454 | 0.74 | BACE1 (0.58) | CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |