Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220170 | 0.73 | ALDH1A1 (0.44) | MAPTPOLB | |
| SCHEMBL5222330 | 0.70 | ALDH1A1 (0.45) | MAPTPOLB | |
| SCHEMBL5219656 | 0.69 | ALDH1A1 (0.42) | TSHRMAPTPOLBL3MBTL1 | |
| SCHEMBL6727081 | 0.68 | TSHR (0.56) | TSHRMAPTPOLBL3MBTL1 | |
| SCHEMBL5222223 | 0.67 | MAPT (0.38) | TSHRGAAMAPT | |
| SCHEMBL5218309 | 0.66 | VCAM1 (0.42) | MAPTPOLB | |
| SCHEMBL29634343 | 0.66 | TSHR (0.53) | TSHRPOLBL3MBTL1 | |
| SCHEMBL11756245 | 0.66 | TSHR (0.53) | TSHRPOLBL3MBTL1 | |
| SCHEMBL4581662 | 0.66 | TSHR (0.53) | TSHRMAPTPOLBL3MBTL1 | |
| SCHEMBL31636358 | 0.64 | TSHR (0.56) | TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |