Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220401 | 0.92 | CCR2 (0.61) | CCR2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL5219974 | 0.88 | CCR2 (0.63) | CCR2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL5214826 | 0.87 | CCR2 (0.48) | CCR2ALDH1A1HTTNCOA1NCOA3 | |
| SCHEMBL7467238 | 0.83 | CCR2 (0.58) | CCR2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL5214833 | 0.80 | CCR2 (0.48) | CCR2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL5216530 | 0.80 | CCR2 (0.68) | CCR2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL6599738 | 0.77 | CCR2 (1.00) | CCR2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL5215970 | 0.76 | CCR2 (0.50) | CCR2ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL6302591 | 0.76 | CCR2 (1.00) | CCR2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL6307042 | 0.74 | CCR2 (0.77) | CCR2ALDH1A1HTTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |