Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | COPS5 | Q92905 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12292832 | 0.85 | ALDH1A1 (0.41) | PKMALDH1A1COPS5MAPTCYP1A2 | |
| SCHEMBL18176042 | 0.84 | FBP1 (0.43) | PKMALDH1A1COPS5MAPTCYP1A2 | |
| SCHEMBL11316972 | 0.82 | ALDH1A1 (0.37) | PKMALDH1A1COPS5MAPTCYP1A2 | |
| SCHEMBL13068462 | 0.81 | ALDH1A1 (0.37) | PKMALDH1A1COPS5MAPTCYP1A2 | |
| SCHEMBL2624097 | 0.80 | KDM4E (0.42) | PKMALDH1A1MAPTCYP1A2NPC1 | |
| SCHEMBL11324056 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPTCYP1A2NPC1RAB9A | |
| SCHEMBL9644143 | 0.78 | PKM (0.40) | PKMALDH1A1CYP1A2NPC1RAB9A | |
| SCHEMBL9372680 | 0.78 | ALDH1A1 (0.41) | PKMALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL9643967 | 0.77 | ALDH1A1 (0.58) | PKMALDH1A1COPS5MAPTNPC1 | |
| SCHEMBL9644022 | 0.77 | PKM (0.39) | PKMALDH1A1RAB9ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108084111-A | A kind of synthetic method of aminated compounds of the pharmaceutical intermediate containing sulfur nitrogen heterocycle | 北京六合宁远科技有限公司 | 2018-05-29 | — | — | CN | disclosed |
| EP-2532662-B1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | NANJING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD (CN) | 2016-01-27 | — | — | EP | disclosed |
| US-9108954-B2 | Synthesis process of dasatinib and intermediate thereof | NAN JING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD. (CN) | 2015-08-18 | — | — | US | disclosed |
| CN-101959882-B | Imidazole carbonyl compound | DAIICHI SANKYO CO LTD | 2013-09-11 | — | — | CN | disclosed |
| US-20130030177-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nan Jing Cavendish Bio-Engineering Technology Co. Ltd. (CN) | 2013-01-31 | — | — | US | disclosed |
| EP-2532662-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | Nanjing Cavendish Bio-Engineering Technology Co., Ltd. (CN) | 2012-12-12 | — | — | EP | disclosed |
| CN-101959882-A | Imidazole carbonyl compound | DAIICHI SANKYO CO LTD | 2011-01-26 | — | — | CN | disclosed |
| EP-1525193-B1 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-12-26 | — | — | EP | disclosed |
| EP-1525193-A2 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004009565-A2 | ACYLAMINOTHIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-01-29 | — | — | WO | disclosed |
| US-4602937-A | PLANT SAFENING AGENTS, ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4602454-A | PLANT SAFENING AGENTS, SEEDS CHLOROACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4437876-A | PLANT SAFENING AGENTS FOR ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4437875-A | PLANT SAFENING AGENT FOR ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4199506-A | REDUCES HERBICIDAL INJURY TO PLATNS DUE TO ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030177-A1 | SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF | ABL1, YES1, ABL2 | PKM 1740/4885ALDH1A1 1094/4885COPS5 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.