Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221149 | 0.96 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5220487 | 0.88 | KDM4E (0.47) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5221138 | 0.84 | KDM4E (0.49) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5219772 | 0.83 | KDM4E (0.47) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5222641 | 0.81 | CTSD (0.41) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5223575 | 0.78 | TPMT (0.43) | KDM4ESMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL5217576 | 0.78 | KDM4E (0.33) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5218055 | 0.78 | CTSD (0.44) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5217580 | 0.78 | KDM4E (0.33) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL5222780 | 0.77 | KDM4E (0.38) | KDM4ESMN1; SMN2NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |