Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218055 | 0.97 | CTSD (0.44) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5218045 | 0.91 | CTSD (0.42) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5222633 | 0.89 | CTSD (0.48) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5220759 | 0.88 | BACE1 (0.45) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5218051 | 0.86 | BACE1 (0.51) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5218025 | 0.84 | BACE1 (0.41) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5220495 | 0.81 | KDM4E (0.44) | ALDH1A1KDM4ETSHRSMN1; SMN2MEN1 | |
| SCHEMBL5218053 | 0.80 | CTSD (0.49) | CTSDBACE1BACE2PDE4BPDE4D | |
| SCHEMBL5221149 | 0.78 | KDM4E (0.46) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5222480 | 0.77 | CTSD (0.44) | CTSDBACE1BACE2PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |