Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222772 | 0.88 | KDM4E (0.41) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5223226 | 0.86 | KDM4E (0.38) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5220767 | 0.82 | ALDH1A1 (0.42) | KDM4ESMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL5221149 | 0.81 | KDM4E (0.46) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5220495 | 0.77 | KDM4E (0.44) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5218548 | 0.74 | NPC1 (0.40) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5223229 | 0.74 | KDM4E (0.41) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5217576 | 0.73 | KDM4E (0.33) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A | |
| SCHEMBL5223575 | 0.73 | TPMT (0.43) | KDM4ESMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL5218055 | 0.73 | CTSD (0.44) | KDM4ENPC1NPSR1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |