Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389296 | 0.85 | GRIN2B (0.43) | GRIN2BCYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL4665129 | 0.82 | GPR119 (0.43) | PRMT5WDR77GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL4036422 | 0.80 | GPR119 (0.54) | GPR119 | |
| SCHEMBL3396290 | 0.79 | PRMT5 (0.47) | PRMT5WDR77MEN1KMT2AKCNH2 | |
| SCHEMBL4666838 | 0.77 | GRIN2B (0.44) | GRIN2BKCNH2 | |
| SCHEMBL4957480 | 0.77 | CYP46A1 (0.52) | CYP2C9MEN1KMT2ACYP46A1SPR | |
| SCHEMBL3397914 | 0.76 | PRMT5 (0.45) | PRMT5WDR77MEN1KMT2AKCNH2 | |
| SCHEMBL3402131 | 0.76 | PPARG (0.42) | PRMT5WDR77GRIN2BMEN1KMT2A | |
| SCHEMBL16600250 | 0.76 | SPR (0.50) | CYP2C9MEN1KMT2ACYP46A1SPR | |
| Hydrochloric Acid SCHEMBL3398254 | 0.75 | PRMT5 (0.44) | PRMT5WDR77MEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789410-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006029906-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-03-23 | — | — | WO | disclosed |