Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | USP19 | O94966 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397914 | 0.90 | PRMT5 (0.45) | PPARGPPARAPRMT5WDR77MGLL | |
| Hydrochloric Acid SCHEMBL3398254 | 0.89 | PRMT5 (0.44) | PPARGPPARAPRMT5WDR77MGLL | |
| SCHEMBL3400356 | 0.86 | MGLL (0.49) | PPARGPPARAGPR119GRIN2BPRMT5 | |
| SCHEMBL1364206 | 0.85 | HDAC1 (0.45) | GPR119FAAH | |
| SCHEMBL12062876 | 0.85 | LOXL2 (0.39) | GRIN2BUSP19LOXL2MGLL | |
| SCHEMBL3396290 | 0.77 | PRMT5 (0.47) | PRMT5WDR77MGLLMEN1KMT2A | |
| SCHEMBL5220949 | 0.76 | PRMT5 (0.47) | GPR119GRIN2BPRMT5WDR77MEN1 | |
| SCHEMBL3402093 | 0.74 | ALDH1A1 (0.48) | MGLLMEN1KMT2AFAAH | |
| SCHEMBL1363667 | 0.74 | KDM4E (0.48) | GPR119F2F10PLGST14 | |
| SCHEMBL12062875 | 0.73 | MGLL (0.42) | MGLLF2F10PLGST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |