Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.56 |
| ▸ | ELANE | P08246 | 7/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884041 | 0.91 | P2RX7 (0.57) | P2RX7ELANEDYRK1AMALT1AVPR1A | |
| SCHEMBL5111601 | 0.81 | P2RX7 (0.81) | P2RX7ELANEDYRK1AMALT1CYP3A4 | |
| SCHEMBL4881090 | 0.81 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL5218229 | 0.80 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL5118323 | 0.76 | P2RX7 (0.75) | P2RX7 | |
| SCHEMBL4881893 | 0.74 | P2RX7 (0.60) | P2RX7DYRK1A | |
| SCHEMBL4880597 | 0.73 | P2RX7 (0.59) | P2RX7AVPR1A | |
| SCHEMBL4881926 | 0.72 | P2RX7 (0.55) | P2RX7AVPR1AKMT2A | |
| SCHEMBL5111591 | 0.72 | P2RX7 (1.00) | P2RX7ELANEDYRK1AMALT1KMT2A | |
| SCHEMBL4890962 | 0.71 | P2RX7 (0.54) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786786-A1 | ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006025783-A1 | ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |