Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 12/20 | 0.46 |
| ▸ | BACE1 | P56817 | 12/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217461 | 0.97 | ALDH1A1 (0.47) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5221058 | 0.93 | USP2 (0.46) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5217257 | 0.91 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5222337 | 0.90 | USP2 (0.46) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5217571 | 0.87 | CTSD (0.51) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5223281 | 0.85 | CTSD (0.48) | ALDH1A1CTSDBACE1BACE2CYP1A2 | |
| SCHEMBL5222224 | 0.83 | ALDH1A1 (0.51) | ALDH1A1HSD17B10CTSDBACE1BACE2 | |
| SCHEMBL5220917 | 0.83 | CTSD (0.49) | ALDH1A1CTSDBACE1BACE2GAA | |
| SCHEMBL5224797 | 0.83 | MEN1 (0.44) | ALDH1A1CTSDBACE1BACE2CYP1A2 | |
| SCHEMBL5223014 | 0.82 | CTSD (0.48) | ALDH1A1HSD17B10CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |