Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 11/20 | 0.43 |
| ▸ | BACE1 | P56817 | 11/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221058 | 0.96 | USP2 (0.46) | USP2CTSDBACE1BACE2ALDH1A1 | |
| SCHEMBL5222055 | 0.90 | ALDH1A1 (0.51) | USP2CTSDBACE1BACE2ALDH1A1 | |
| SCHEMBL5221595 | 0.89 | USP2 (0.49) | USP2CTSDBACE1BACE2ALDH1A1 | |
| SCHEMBL5217461 | 0.89 | ALDH1A1 (0.47) | USP2CTSDBACE1BACE2ALDH1A1 | |
| SCHEMBL5222224 | 0.87 | ALDH1A1 (0.51) | USP2CTSDBACE1BACE2ALDH1A1 | |
| SCHEMBL5223281 | 0.84 | CTSD (0.48) | CTSDBACE1BACE2ALDH1A1HPGD | |
| SCHEMBL5224797 | 0.81 | MEN1 (0.44) | CTSDBACE1BACE2ALDH1A1HPGD | |
| SCHEMBL5220917 | 0.81 | CTSD (0.49) | CTSDBACE1BACE2ALDH1A1HPGD | |
| SCHEMBL5223014 | 0.81 | CTSD (0.48) | CTSDBACE1BACE2ALDH1A1HSD17B10 | |
| SCHEMBL5218504 | 0.80 | USP2 (0.52) | USP2ALDH1A1HSD17B10POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |