Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 7/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.48 |
| ▸ | LCK | P06239 | 7/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341764 | 0.89 | DYRK1A (0.52) | AURKATGFBR1LIMK1LIMK2ERN1 | |
| SCHEMBL1845567 | 0.87 | KDM4E (0.56) | AURKAKDRRIPK2TGFBR1LIMK1 | |
| SCHEMBL29627363 | 0.87 | KDM4E (0.56) | AURKAKDRRIPK2TGFBR1LIMK1 | |
| SCHEMBL4155826 | 0.83 | NPC1 (0.53) | KDRRIPK2TGFBR1LCKFASN | |
| Hydrochloric Acid SCHEMBL6384354 | 0.82 | NPC1 (0.51) | KDRRIPK2TGFBR1LCKFASN | |
| SCHEMBL28048502 | 0.78 | ALDH1A1 (0.54) | AURKAKDRRIPK2TGFBR1LCK | |
| SCHEMBL13394458 | 0.77 | MAP4K4 (0.49) | AURKAKDRRIPK2TGFBR1LCK | |
| SCHEMBL29478085 | 0.76 | RIPK2 (0.60) | AURKAKDRRIPK2TGFBR1LCK | |
| SCHEMBL927048 | 0.76 | RIPK2 (0.60) | AURKAKDRRIPK2TGFBR1LCK | |
| SCHEMBL31324974 | 0.76 | PIK3CA (0.55) | LIMK1LIMK2ERN1CCNT1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | claimed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | claimed |
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | claimed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | claimed |
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |