Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 5/20 | 0.71 |
| ▸ | WNT3A | P56704 | 5/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.68 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9151008 | 0.93 | CTNNB1 (0.65) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL9154202 | 0.92 | CTNNB1 (0.64) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL5162760 | 0.88 | NR4A2 (0.67) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL29456920 | 0.88 | NR4A2 (0.67) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL8959965 | 0.86 | CTNNB1 (0.68) | CTNNB1WNT3AADAM17KDM1ALMNA | |
| SCHEMBL31588418 | 0.84 | CTNNB1 (0.68) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL15968882 | 0.83 | CTNNB1 (1.00) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL9633079 | 0.83 | ADAM17 (0.73) | CTNNB1WNT3AADAM17NR4A2CREBBP | |
| SCHEMBL7214385 | 0.81 | ADAM17 (1.00) | CTNNB1WNT3AADAM17NR4A2KDM1A | |
| SCHEMBL5220143 | 0.81 | NR4A2 (0.67) | NR4A2LMNAMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618094-B1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | INST FOR PHARM DISCOVERY INC (US) | 2007-09-05 | — | — | EP | disclosed |
| US-20050009817-A1 | Substituted heteroaryls | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | PTPRS, PTPRO, PTPRR | CTNNB1 3737/4885WNT3A 3833/4885ADAM17 4581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.