Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 1.00 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.79 |
| ▸ | WNT3A | P56704 | 5/20 | 0.79 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15969761 | 0.89 | CTNNB1 (1.00) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL6518029 | 0.85 | ADAM17 (0.73) | ADAM17CTNNB1WNT3AGPR84LMNA | |
| SCHEMBL9633079 | 0.85 | ADAM17 (0.73) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL9048121 | 0.83 | ADAM17 (0.71) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL15988871 | 0.83 | ADAM17 (0.70) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL15968498 | 0.83 | CTNNB1 (1.00) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL30441098 | 0.83 | ADAM17 (0.70) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL15968866 | 0.83 | ADAM17 (0.70) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL5222554 | 0.81 | CTNNB1 (0.71) | ADAM17CTNNB1WNT3AGPR84KDM1A | |
| SCHEMBL17929695 | 0.81 | CTNNB1 (0.72) | ADAM17CTNNB1WNT3AGPR84KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1155568-C | Method for producing 3-alkanoylindoles and 3-alkylindoles | Ĭ��ר���ɷ�����˾ | 2004-06-30 | — | — | CN | disclosed |
| US-6509475-B1 | Friedel-Crafts acylation catalyzed by Lewis acid alkylaluminum dichloride; chemical reduction, salt formation | MERCK PATENT GMBH (DE) | 2003-01-21 | — | — | US | disclosed |
| CN-1330635-A | Method for producing 3-alkanoylindoles and 3-alkylindoles | MERCK PATENT GMBH (DE) | 2002-01-09 | — | — | CN | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |