SCHEMBL522278

SCHEMBL522278

O=C(OCc1ccccc1)C1CCCCC1

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FABP7 O15540 1/20 0.54
FABP5 Q01469 1/20 0.54
TSHR P16473 1/20 0.54
ALDH1A1 P00352 4/20 0.52
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
EPHX1 P07099 1/20 0.51
FKBP1A P62942 2/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31518977 1.00 FABP7 (0.54) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL2703515 0.98 FABP7 (0.55) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL3664444 0.95 TSHR (0.58) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL10917021 0.91 FABP7 (0.58) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL6666657 0.91 FABP7 (0.58) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL280126 0.91 FABP7 (0.58) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL17365604 0.91 CYP3A4 (0.53) FABP7FABP5TSHRALDH1A1NPC1
SCHEMBL11982183 0.91 CYP3A4 (0.53) FABP7FABP5TSHRALDH1A1NPC1
Hydrochloric Acid SCHEMBL27944947 0.89 FABP7 (0.57) FABP7FABP5TSHRALDH1A1NPC1
Hydrochloric Acid SCHEMBL27765522 0.89 FABP7 (0.57) FABP7FABP5TSHRALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8211884-B2 2,2-Dimethyl-4-oxo-4-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-[1,4]diazepan-1-yl)-butyric acid, hydrochloride; obesity, type II diabetes mellitus and metabolic syndrome MADRIGAL PHARMACEUTICALS, INC. (US) 2012-07-03 US claimed
WO-2010017040-A1 DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS VIA PHARMACEUTICALS, INC (US) 2010-02-11 WO claimed
US-20100035864-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2010-02-11 US claimed
EP-0687249-A1 BALANOIDS ELI LILLY AND COMPANY (US) 1995-12-20 EP claimed
WO-1994020062-A2 BALANOIDS AS PROTEIN KINASE C INHIBITORS ELI LILLY AND COMPANY (US) 1994-09-15 WO claimed
JP-62006681-A None JP disclosed
EP-4743522-A1 COMPOSITION OF THERMOPLASTIC POLYMER, PLASTICIZER, AND LOW MELTING POLYMER Avient Corporation (US) 2026-05-20 EP disclosed
CN-119591496-A Method for catalyzing cycloalkane oxidative carbonylation reaction by metal-based ionic liquid 中国科学院过程工程研究所 2025-03-11 CN disclosed
WO-2025019282-A1 COMPOSITION OF THERMOPLASTIC POLYMER, PLASTICIZER, AND LOW MELTING POLYMER AVIENT CORPORATION (US) 2025-01-23 WO disclosed
US-20250019533-A1 COMPOSITION OF THERMOPLASTIC POLYMER, PLASTICIZER, AND LOW MELTING POLYMER AVIENT CORPORATION (US) 2025-01-16 US disclosed
CN-117677603-A Cyclohexane lipids for nucleic acid transfection and uses thereof 捷克有机化学和生物化学研究院 2024-03-08 CN disclosed
WO-2023086399-A1 BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF NURIX THERAPEUTICS, INC. (US) 2023-05-19 WO disclosed
CN-1300730-A Process for preparing aminoformate compounds with CO2 instead of severely toxic optical gas SHANGHAI INST ORGANIC CHEM (CN) 2001-06-27 CN disclosed
EP-1004621-A1 GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME TEIJIN LIMITED (JP) 2000-05-31 EP disclosed
EP-0687249-A1 BALANOIDS ELI LILLY AND COMPANY (US) 1995-12-20 EP disclosed
WO-1994020062-A2 BALANOIDS AS PROTEIN KINASE C INHIBITORS ELI LILLY AND COMPANY (US) 1994-09-15 WO disclosed
CN-1015361-B ENANTIOMERIC GLUTARAMIDE DIURETIC AGENTS PFIZER (US) 1992-02-05 CN disclosed
CN-1037704-A The glutaramide diuretic agents of enantiomorph PFIZER (US) 1989-12-06 CN disclosed
JP-S626681-A PROTEASE INHIBITOR SHOWA DENKO KK 1987-01-13 JP disclosed
US-4178317-A Manufacture of olefinically unsaturated aliphatic or cycloaliphatic hydrocarbons BASF AKTIENGESELLSCHAFT (DE) 1979-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035864-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT FABP7 616/4885FABP5 447/4885TSHR 2286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.