Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222991 | 0.81 | EPHX2 (0.41) | EPHX2 | |
| SCHEMBL5223476 | 0.80 | BACE1 (0.44) | BACE1 | |
| SCHEMBL5223435 | 0.80 | BACE1 (0.42) | BACE1 | |
| SCHEMBL4693111 | 0.80 | BACE1 (0.41) | BACE1 | |
| SCHEMBL4693114 | 0.80 | BACE1 (0.41) | BACE1 | |
| SCHEMBL5223477 | 0.80 | BACE1 (0.44) | BACE1 | |
| SCHEMBL5223473 | 0.79 | OPRD1 (0.41) | BCHEBACE1OPRM1OPRD1OPRK1 | |
| SCHEMBL5223463 | 0.79 | OPRD1 (0.41) | BCHEBACE1OPRM1OPRD1OPRK1 | |
| SCHEMBL5219187 | 0.79 | SIGMAR1 (0.43) | BCHEBACE1OPRM1OPRD1OPRK1 | |
| SCHEMBL5219195 | 0.79 | SIGMAR1 (0.43) | BCHEBACE1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |