Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221408 | 0.79 | KDM4E (0.46) | MAP4K4ADORA2AADORA1NOTUM | |
| SCHEMBL22588702 | 0.77 | SMARCA2 (0.53) | TDO2MAP4K4ADORA2AADORA1NOTUM | |
| SCHEMBL11902083 | 0.76 | MAP4K4 (0.56) | DHFRTDO2MAP4K4NUDT1ADORA2A | |
| Hydrochloric Acid SCHEMBL27209691 | 0.76 | SMARCA2 (0.52) | TDO2MAP4K4ADORA2AADORA1NPC1 | |
| SCHEMBL21223518 | 0.74 | DHFR (0.61) | DHFRTDO2MAP4K4ADORA2AADORA1 | |
| SCHEMBL5005153 | 0.72 | MAPK14 (0.48) | NUDT1ADORA2AADORA1NOTUM | |
| SCHEMBL2417817 | 0.71 | ALDH1A1 (0.46) | ADORA2AADORA1NOTUMNPC1RAB9A | |
| SCHEMBL31728471 | 0.70 | MAP4K4 (0.53) | DHFRTDO2MAP4K4NUDT1ADORA2A | |
| SCHEMBL21933948 | 0.69 | ALDH1A1 (0.50) | DHFRTDO2ADORA2AADORA1NPC1 | |
| SCHEMBL913810 | 0.69 | NOTUM (0.47) | NOTUMNPC1RAB9ATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | claimed |