Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223234 | 0.79 | DHFR (0.51) | NOTUMMAP4K4ADORA2AADORA1 | |
| SCHEMBL28075469 | 0.78 | TDO2 (0.43) | NOTUMMAP4K4PRKACACDK2GSK3B | |
| SCHEMBL22588702 | 0.77 | SMARCA2 (0.53) | NOTUMMAP4K4GSK3BCLK4ADORA2A | |
| SCHEMBL17555726 | 0.76 | FYN (0.49) | KDM4ETAAR1FYNMEN1MAPT | |
| Hydrochloric Acid SCHEMBL27209691 | 0.76 | SMARCA2 (0.52) | MAP4K4GSK3BCLK4ADORA2AADORA1 | |
| SCHEMBL21994858 | 0.75 | KDM4E (0.45) | KDM4ETAAR1NOTUMFYNMEN1 | |
| SCHEMBL18748036 | 0.70 | ADORA2A (0.57) | KDM4ETAAR1NOTUMMEN1MAPT | |
| SCHEMBL27862933 | 0.69 | GABRG2 (0.48) | KDM4ETAAR1NOTUMMEN1MAPT | |
| SCHEMBL28878344 | 0.69 | NOTUM (0.44) | KDM4ETAAR1NOTUMADORA2AADORA1 | |
| SCHEMBL4470993 | 0.69 | CHEK2 (0.56) | KDM4ETAAR1FYNMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | claimed |