Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23708489 | 0.89 | KDM4E (0.53) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL5224122 | 0.76 | ALDH1A1 (0.53) | HTTKDM4EMEN1MAPTKMT2A | |
| SCHEMBL8782056 | 0.73 | CSNK1A1 (0.54) | CSNK1A1TYRO3DYRK1BPARP1KDM4E | |
| SCHEMBL3538450 | 0.71 | NPC1 (0.63) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL3085532 | 0.70 | NPC1 (0.61) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL3086459 | 0.70 | NPC1 (0.61) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL2351161 | 0.70 | NISCH (0.53) | NPC1HTTKDM4EMEN1MAPT | |
| SCHEMBL22732072 | 0.69 | CSNK1A1 (0.40) | CDC7ROCK2MAP4K4CDK2GSK3B | |
| SCHEMBL3715090 | 0.69 | ALDH1A1 (0.59) | GSK3BNPC1KDM4EMEN1KMT2A | |
| SCHEMBL4959047 | 0.68 | CDC7 (0.58) | CDC7ROCK2MAP4K4CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812425-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006047479-A2 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |