Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4467486 | 0.99 | CYP11B1 (0.41) | CYP11B1GRM4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2677845 | 0.98 | CYP11B1 (0.43) | CYP11B1GRM4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2678469 | 0.95 | CYP11B1 (0.45) | CYP11B1GRM4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4463632 | 0.81 | CYP11B1 (0.41) | CYP11B1GRM4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5217419 | 0.79 | CYP11B1 (0.38) | CYP11B1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| Bromide SCHEMBL4472191 | 0.78 | CYP11B1 (0.37) | CYP11B1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL4463296 | 0.77 | HSD11B1 (0.40) | — | |
| SCHEMBL5223363 | 0.76 | HCRTR1 (0.31) | — | |
| SCHEMBL4442686 | 0.76 | CYP11B1 (0.39) | CYP11B1RAB9ASMN1; SMN2MAPTKDM4E | |
| Bromide SCHEMBL4471147 | 0.76 | HSD11B1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465893-B1 | DERIVATIVES OF 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, THE PREPARATION THEREOF AND THE APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2007-02-28 | — | — | EP | claimed |