Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 4/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041567 | 0.94 | KDM1A (0.49) | CTSDBACE1BACE2KDM1AMAOA | |
| SCHEMBL4045255 | 0.94 | KDM1A (0.49) | CTSDBACE1BACE2KDM1AMAOA | |
| SCHEMBL3347460 | 0.84 | MAOA (0.46) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL5218704 | 0.84 | MAOA (0.46) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL5219956 | 0.84 | MAOA (0.46) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL7048871 | 0.84 | MAOA (0.46) | CTSDBACE1BACE2MAOAMAOB | |
| SCHEMBL13306179 | 0.82 | BACE1 (0.56) | CTSDBACE1KDM1AMAOAMAOB | |
| SCHEMBL3913679 | 0.82 | BACE1 (0.56) | CTSDBACE1KDM1AMAOAMAOB | |
| SCHEMBL5224073 | 0.81 | BACE1 (0.48) | CTSDBACE1BACE2KDM1AMAOA | |
| SCHEMBL5224081 | 0.81 | BACE1 (0.48) | CTSDBACE1BACE2KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |