Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347460 | 1.00 | MAOA (0.46) | MAOAMAOBBCHEADRA2BADRA2C | |
| SCHEMBL5219956 | 1.00 | MAOA (0.46) | MAOAMAOBBCHEADRA2BADRA2C | |
| SCHEMBL7048871 | 1.00 | MAOA (0.46) | MAOAMAOBBCHEADRA2BADRA2C | |
| SCHEMBL4041822 | 0.93 | ALDH1A1 (0.50) | CTSDBACE1EPHX2ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL5225065 | 0.92 | ALDH1A1 (0.49) | CTSDBACE1EPHX2ALDH1A1HTT | |
| SCHEMBL5223365 | 0.84 | CTSD (0.49) | MAOAMAOBACHECTSDBACE1 | |
| SCHEMBL3357325 | 0.81 | BACE1 (0.55) | MAOAMAOBCTSDBACE1BACE2 | |
| SCHEMBL3357333 | 0.81 | BACE1 (0.55) | MAOAMAOBCTSDBACE1BACE2 | |
| SCHEMBL4042654 | 0.80 | BACE1 (0.48) | CTSDBACE1BACE2ALDH1A1HTT | |
| SCHEMBL5805296 | 0.78 | GRIN2B (0.48) | CTSDBACE1BACE2GRIN2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |